pretty thingUoP maths seminar (2013-14)

Mathematical Modelling of Cardiac Rhythms in Health and Disease.

Speaker: Harry Green (University of Exeter)

Venue: Wednesday 23rd April 2014, 1pm, LG2.04a (refreshments provided)

Abstract: Mathematical modelling of the cardiac conduction system has largely been dominated by very large systems of computationally expensive and analytically intractable biophysical models. While accurate and biologically relevant, the computation time (measured in days rather than seconds) leads to reduced practicality in clinical applications. I will present phenomenological models for both the cardiac pacemakers (sinoatrial and atrioventricular nodes) and for the electrical propagation of cardiac action potentials across the atria and ventricular myocardium. The models presented are largely based on van der Pol-Duffing oscillators and the FitzHugh-Nagumo model for excitable media. The project is in collaboration with the Bristol Heart Institute, with the eventual goal of providing heart surgeons with a tool to guide the potentially dangerous procedure of treating cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia through radio frequency ablation therapy.